Q15642

CIP4 (Cdc42-interacting protein 4), also known as TRIP10 (thyroid hormone receptor interactor 10), STOT, STP or HSTP, is a 601 amino acid protein that localizes to the cytoplasm and the cytoskeleton, as well as to the lysosome and the golgi apparatus and contains one FCH domain, one SH3 domain and one REM repeat. Expressed in a variety of tissues, including kidney, brain, liver, lung, heart and pancreas, CIP4 is required for the Insulin-dependent translocation of Glut4 to the plasma membrane and is essential for the coordination of membrane tubulation with Actin cytoskeletal reorganization during endocytosis. CIP4 exists as multiple alternative spliced isoforms and is subject to post-translational tyrosine phosphorylation. Aberrant splicing events during CIP4 transcription are associated with the pathogenesis of renal cell carcinoma, suggesting a role for CIP4 in tumor transformation and metastasis.