Monoclonal Antibodies - ASK1 Mouse Monoclonal Antibody

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ASK1 Mouse Monoclonal Antibody

Catalog #：EAB21873

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21873-100UL	In Stock	100ul	€258.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB, IHC-P, IF/ICC, FC, ELISA
Species Reactivity	Human
Host / Isotype	Mouse IgG1
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:100-500 IF/ICC=1:100-500 FC=1:50-200
MW (kDa)	155
Conjugate	Unconjugate
Specificity	ASK1 Mouse Monoclonal Antibody detects endogenous levels of ASK1 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Mitogen-activated protein kinase kinase kinase 5; ASK1; MEKK5; MAPKKK5; MAP3K5
Gene Aliases	MAP3K5
UniProt ID	Q99683
Entrez Gene ID	4217

Product Description

ASK1 also known as MEKK5, MAP3K5 is a member of the MAP kinase kinase kinase subfamily. ASK1 plays a crucial role in cellular signaling pathways, particularly in the activation of mitogen-activated protein (MAP) kinase cascades, which are essential for mediating cellular responses to various extracellular stimuli, including stress and growth factors. ASK1 is primarily located in the cytoplasm, where ASK1 acts as a key regulator of apoptosis and inflammation by activating downstream kinases such as MEK-4 and MEK-3/MEK-6. This localization allows ASK1 to respond rapidly to cellular stress signals, thereby influencing cell survival and death decisions. ASK1′s ability to modulate these pathways underscores ASK1′s importance in various physiological and pathological processes, including cancer and neurodegenerative diseases.

Product Image Gallery
Western blot analysis of extracts on HEK293 cells, using ASK1 Mouse Monoclonal Antibody (EAB21873) at 1:2000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol