Recombinant Antibodies - SirT5 Rabbit Monoclonal Antibody

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SirT5 Rabbit Monoclonal Antibody

Catalog #：EAB21849

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21849-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	Betaclonal	Phone：+34 (0)91 471 6763
	29/1 Lomonosovsky Pr,	E-mail：tech@betaclonal.com
Spain	Madrid, Spain	Web：www.betaclonal.com

Product Information
Applications	WB
Species Reactivity	Human, Mouse
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	34
Conjugate	Unconjugate
Specificity	SirT5 Rabbit Monoclonal Antibody detects endogenous levels of SirT5 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Sirtuin 5; SIR2L5; SIRT5
Gene Aliases	SIRT5
UniProt ID	Q9NXA8
Entrez Gene ID	23408

Product Description

SirT5(Sirtuin 5) is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. SIRT5 is primarily localized in mitochondria, where SIRT5 plays a significant role in metabolic regulation and may influence aging processes in humans. Mitochondrial localization of SIRT5 enables direct interaction with various metabolic pathways, including fatty acid oxidation and urea cycle. SIRT5 deacetylates specific mitochondrial proteins, modulating their activity and contributing to overall metabolic homeostasis of cells. Suramin can inhibit SIRT5 by disrupting growth factor binding, highlighting SIRT5′s potential as a therapeutic target in metabolic disorders. Two SIRT5 isoforms arise from alternative splicing, further diversifying functional roles within cells.

Product Image Gallery
Western blot analysis of extracts on Jurkat cells, using SirT5 Rabbit Monoclonal Antibody (EAB21849) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol