TFG(TRK fused gene) also known as TRK-T3 is a fusion protein resulting from oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, and is particularly significant in thyroid carcinomas where these rearrangements are frequently observed. TFG protein is characterized by a coiled-coil motif within the TFG region, which is crucial for forming protein complexes, thereby facilitating various signaling pathways. This structural feature allows TFG to interact with key adaptor proteins such as Shc and SNT1/FRS2, which play essential roles in linking receptor tyrosine kinases to the mitogen-activated protein kinase pathway, ultimately influencing cellular proliferation and survival.