Recombinant Antibodies - RUNX1/RUNX2/RUNX3 Rabbit Monoclonal Antibody

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RUNX1/RUNX2/RUNX3 Rabbit Monoclonal Antibody

Catalog #：EAB21360

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21360-100UL	In Stock	100ul	￡251.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IP, IHC-P, IF/ICC, FC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IP=1:10-100　 IHC-P=1:50-200　 IF/ICC=1:50-200　 FC=1:10-100
MW (kDa)	49
Conjugate	Unconjugate
Specificity	RUNX1/RUNX2/RUNX3 Rabbit Monoclonal Antibody detects endogenous levels of RUNX1/RUNX2/RUNX3 protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	RUNX family transcription factor 1; RUNX family transcription factor 2; RUNX family transcription factor 3; CCD; AML3; CCD1; CLCD; OSF2; CBFA1; OSF-2; PEA2aA; PEBP2aA; CBF-alpha-1; AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; CBF2alpha; AML1-EVI-1; PEBP2alpha; AML2; CBFA3; PEBP2aC; RUNX1; RUNX2; RUNX3
Gene Aliases	RUNX1/RUNX2/RUNX3
UniProt ID	Q01196, Q13950, Q13761
Entrez Gene ID	861, 860, 864

Product Description

The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1, RUNX2 and RUNX3. RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX1 plays a critical role in hematopoiesis, the process of blood cell formation, and is essential for proper development of various blood cell lineages. RUNX1 regulates the expression of genes involved in cellular differentiation and cell cycle progression, making RUNX1 a key player in maintaining normal hematopoietic function. RUNX1 is frequently implicated in human leukemia due to chromosomal translocations that disrupt DNA-binding domain, leading to aberrant gene expression and oncogenesis. RUNX2 plays a critical role in skeletal development and mineralization, functioning as a transcription factor that regulates the expression of genes essential for osteoblast differentiation and bone formation. RUNX3 plays a crucial role in regulating gene expression related to cellular differentiation and cell cycle progression. RUNX3 is predominantly expressed in hematopoietic cells, including myeloid and B-cell lines, as well as in the spleen.

Product Image Gallery
Western blot analysis of extracts on Jurkat cells, using RUNX1/RUNX2/RUNX3 Rabbit Monoclonal Antibody (EAB21360) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol