P46734 

MKK3 also known as MEK3, MAP2K3 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. MKK3 plays a crucial role in the activation of the p38 MAP kinase pathway, which is essential for cellular responses to stress and inflammation. By phosphorylating specific threonine and tyrosine residues on p38 MAP kinase, MEK-3 facilitates the transmission of signals that regulate various biological processes, including cell differentiation, apoptosis, and the immune response. The importance of MEK-3 in these pathways highlights MEK-3′s potential as a therapeutic target in diseases characterized by dysregulated MAP kinase signaling, such as cancer and inflammatory disorders.