Recombinant Antibodies - IKKα Rabbit Monoclonal Antibody

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IKKα Rabbit Monoclonal Antibody

Catalog #：EAB22238

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB22238-100UL	In Stock	100ul	€297.70

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

Please select the country you are in to find your local distributor.

	OlaSciences	Phone：+33 (0) 9 77 4001 556
	87, rue des Suisses 65000 Nanterre,	E-mail：ola@olasciences.com
France	France	Web：www.olasciences.com

Product Information
Applications	WB, IP, IHC-P, IF/ICC, FC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:500-2000　 IP=1:10-100　 IHC-P=1:50-200　 IF/ICC=1:50-200　 FC=1:10-100
MW (kDa)	85
Conjugate	Unconjugate
Specificity	IKKα Rabbit Monoclonal Antibody detects endogenous levels of IKKα protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	I-kappa-B kinase alpha; NFKBIKA; BPS2; IKK1; IKKA; IKBKA; IKK-1; TCF16; IKK-alpha; IKKα; CHUK
Gene Aliases	CHUK
UniProt ID	O15111
Entrez Gene ID	1147

Product Description

IKKα also known as CHUK is a member of the serine/threonine protein kinase family. IKKα plays a pivotal role in activating the transcription factor NFκB, which regulates immune responses and inflammation. Located primarily in the cytoplasm, IKKα phosphorylates the inhibitory protein IκB on specific serine residues, leading to IκB degradation and subsequent NFκB release into the nucleus. This process enables NFκB to translocate and activate genes involved in immune and inflammatory responses. NFκB-inducing kinase (NIK) stimulates IκB phosphorylation by IKKα, serving as a key regulator in signaling pathways activated by tumor necrosis factor (TNF) and interleukin-1 (IL-1). The functional IKK complex, comprising IKKα, IKKβ, and IKKγ (NEMO), is essential for IκB phosphorylation, highlighting IKKα′s role in maintaining cellular homeostasis and responding to inflammatory stimuli.

Product Image Gallery
Western blot analysis of extracts on Hela, K562 cells, using IKKα Rabbit Monoclonal Antibody (EAB22238) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol