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Akt1 Rabbit Monoclonal Antibody
Catalog #£ºEAB21552
  SKU-Pack Size Availability Size Price
EAB21552-100UL In Stock 100ul €297.70
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Dianost Phone£º+49 (0) 40 65472-053
Bullenkoppel 11£¬ 23896 Poggensee, E-mail£ºola@olasciences.com
Germany Germany Web£ºwww.olasciences.com
Product Information
Applications WB, IP, IHC-P, IF/ICC, FC
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Monoclonal
Applications Dilutions WB=1:500-2000¡¡
IP=1:10-100¡¡
IHC-P=1:50-200¡¡
IF/ICC=1:50-200¡¡
FC=1:10-100
MW (kDa) 56
Conjugate Unconjugate
Specificity Akt1 Rabbit Monoclonal Antibody detects endogenous levels of Akt1 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) AKT; AKT1; CWS6; PKB; PKB-ALPHA; PKB/Akt; PKBalpha; PRKBA; RAC; RAC-ALPHA
Gene Aliases AKT1
UniProt ID

P31749

Entrez Gene ID

207

Product Description

The Akt family, comprising Akt1, Akt2, and Akt3, also referred to as protein kinase B isoforms, plays a pivotal role in regulating critical cellular processes, including growth, metabolism, and survival. Akt1, the most extensively studied isoform, is central to anti-apoptotic signaling, translocating from the cytoplasm to the plasma membrane upon activation by upstream kinases such as PI3K and PDK1. This membrane localization allows phosphorylation at Thr308 and Ser473, modifications necessary for full activation and interaction with downstream targets like glycogen synthase kinase-3 beta (GSK-3β) and mammalian target of rapamycin (mTOR). These interactions influence diverse cellular responses, including glucose uptake, protein synthesis, and cell cycle progression. Akt2, predominantly expressed in insulin-responsive tissues, regulates glucose metabolism, while Akt3 is implicated in brain development and function. The precise regulation of these isoforms through phosphorylation and localization underscores their importance in maintaining cellular homeostasis. Dysregulation of Akt signaling is associated with various diseases, including cancer, diabetes, and neurodegenerative disorders.

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Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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