SKU-Pack Size | Availability | Size | Price | |
EAB21237-100UL | In Stock | 100ul | €336.70 |
Please select the country you are in to find your local distributor. |
Dianost | Phone£º+49 (0) 40 65472-053 | |
Bullenkoppel 11£¬ 23896 Poggensee, | E-mail£ºola@olasciences.com | |
Germany | Germany | Web£ºwww.olasciences.com |
Product Information | |
Applications | WB, IP, IHC-P, IF/ICC |
Species Reactivity | Human, Mouse, Rat |
Host / Isotype | Rabbit IgG |
Clonality | Monoclonal |
Applications Dilutions | WB=1:500-2000¡¡ IP=1:10-100¡¡ IHC-P=1:50-200¡¡ IF/ICC=1:50-200¡¡ |
MW (kDa) | 36 |
Conjugate | Unconjugate |
Specificity | Phospho-PP2A (Tyr307) Rabbit Monoclonal Antibody detects endogenous levels of PP2A protein only when phosphorylated at Tyr307. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | PP2CB; PP2Abeta; PP2AB; PP2AA; PP2CB; PP2Aalpha; PP2A¦Á/¦Â; PP2A; PP-2A; PP2A-C; PP2Ac; PP2CA; PPP2CA; PP2Calpha; RP-C; Protein phosphatase 2; PP2A alpha/beta; PP2Aalpha/PP2Abeta |
Gene Aliases | PPP2CB/PPP2CA |
UniProt ID | |
Entrez Gene ID |
Product Description | |
The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr-307 by receptor and nonreceptor protein tyrosine kinases. The catalytic subunit of PP2A is phosphorylated by tyrosine-specific protein kinases and associates with a variety of regulatory subunits. Phosphorylation is enhanced in the presence of the phosphatase inhibitor okadaic acid, consistent with an autodephosphorylation reaction. Phosphorylation is catalyzed by p60v-src, p56lck, epidermal growth factor receptors, and insulin receptors. Transient deactivation of PP2A might enhance transmission of cellular signals through kinase cascades within cells. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. |
Product Image Gallery | |
Western blot analysis of extracts on different cells, using Phospho-PP2A (Tyr307) Rabbit Monoclonal Antibody (EAB21237) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.
Lane1: A431 Lane2: PC12 |
Specific Protocols | |