O60674

Jak2(Janus kinase 2) is a vital member of the non-receptor Janus tyrosine kinase family, integral to the JAK/STAT signaling pathway that regulates essential cellular functions including proliferation, differentiation, and survival within the immune and hematopoietic systems. Upon activation by cytokines and interferons, JAK2 phosphorylates STAT transcription factors, which then dimerize and migrate to the nucleus to modulate gene expression. This signaling mechanism is crucial for maintaining immune homeostasis and orchestrating responses to pathogens. Dysregulation of JAK2 activity is associated with various inflammatory diseases and cancers, highlighting JAK2′s importance as a therapeutic target.