Recombinant Antibodies - Paxillin Rabbit Monoclonal Antibody

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Paxillin Rabbit Monoclonal Antibody

Catalog #：EAB21455

Datasheet

	SKU-Pack Size	Availability	Size	Price
	EAB21455-100UL	In Stock	100ul	￡251.90

If you want to get a larger packsize, Please contact your local distributor or
email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IP, IHC-P, IF/ICC
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Monoclonal
Applications Dilutions	WB=1:1000-5000　 IP=1:10-100　 IHC-P=1:100-500　 IF/ICC=1:100-500
MW (kDa)	65
Conjugate	Unconjugate
Specificity	Paxillin Rabbit Monoclonal Antibody detects endogenous levels of Paxillin protein.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Paxillin; PAXI; PXN
Gene Aliases	PXN
UniProt ID	P49023
Entrez Gene ID	5829

Product Description

Paxillin also known as PXN is a focal adhesion phosphoprotein localized to the cytoskeleton. Paxillin plays a pivotal role in cell adhesion, migration, and signal transduction pathways. Paxillin′s interaction with focal adhesion kinase (FAK) is particularly important, as this interaction is essential for regulating tyrosine phosphorylation in response to cell adhesion. Phosphorylation of paxillin is a key event in signaling pathways activated by various growth factors and oncogenes, which can lead to significant changes in cell behavior, including migration and proliferation. Dynamic regulation of paxillin through tyrosine phosphorylation is vital for reorganizing the actin cytoskeleton, which is critical for maintaining cell shape and motility.

Product Image Gallery
Western blot analysis of extracts on Hela, Raw264.7 cells, using Paxillin Rabbit Monoclonal Antibody (EAB21455) at 1:1000 dilution. Secondary antibody Goat Anti-Rabbit IgG (H&L)-HRP (EAB21002) at 1:5000 dilution.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol