P11836

CD20 also known as MS4A1 is a member of the membrane-spanning 4A gene family. CD20 play significant roles in cellular signaling. Notably, CD20′s cytoplasmic domain contains multiple phosphorylation sites that can lead to the generation of different isoforms, thereby influencing functional diversity. CD20 is predominantly expressed on B cells, but has also been identified on both normal and neoplastic T cells, highlighting relevance in various immune responses and pathologies. Functionally, CD20 acts as a calcium-permeable cation channel, facilitating transition from G0 to G1 phase of the cell cycle in response to insulin-like growth factor 1 (IGF-1). This activation is mediated through IGF-1 receptor and involves alpha subunits of heterotrimeric G proteins, ultimately leading to increased DNA synthesis, which is thought to be regulated by basic helix-loop-helix leucine zipper transcription factors.