O75473

LGR5 also known as GRP49 is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. LGR5 is a 907 amino acid multi-pass membrane protein characterized by 17 leucine-rich repeats, which are crucial for structural integrity and function as a G protein-coupled receptor. LGR5 protein is predominantly expressed in placenta, skeletal muscle, and spinal cord, where LGR5 plays a vital role as an orphan receptor involved in embryonic growth control and cellular differentiation. The significance of LGR5 extends beyond normal physiological processes; LGR5 overexpression has been linked to increased tumor susceptibility and malignant transformation, highlighting LGR5′s potential as a key player in cancer biology.