Polyclonal Antibodies - Phospho-SREBP-1 (Ser439) Rabbit Polyclonal Antibody

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Phospho-SREBP-1 (Ser439) Rabbit Polyclonal Antibody

Catalog #：EAB14745

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB14745-30UL	In Stock	30ul	￡119.90
EAB14745-100UL	In Stock	100ul	￡251.90
EAB14745-200UL	In Stock	200ul	￡405.90

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB, IHC-P, IF, ELISA
Species Reactivity	Human, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300　 IF=1:50-300
MW (kDa)	122
Conjugate	Unconjugate
Specificity	Phospho-SREBP-1 (Ser439) Rabbit Polyclonal Antibody detects endogenous levels of SREBP-1 only when phosphorylated at Ser439.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	HMD; IFAP2; ADD-1; ADD1; BHLHD1; D630008H06; SREBP-1; SREBP-1a; SREBP-1c; SREBP1; SREBP1a; SREBP1c; SREBF1; BHLHD1; SREBP1; SREBP-1
Gene Aliases	SREBF1
UniProt ID	P36956
Entrez Gene ID	6720

Product Description

SREBP-1 also known as SREBF1 is a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1). SREBP-1 plays a crucial role in lipid metabolism by regulating the expression of genes involved in cholesterol and fatty acid synthesis. SREBP-1 is primarily located in the endoplasmic reticulum and the nuclear envelope, where SREBP-1 exists as a precursor form. Upon sterol depletion, SREBP-1 undergoes proteolytic cleavage, releasing a soluble fragment that translocates to the nucleus to activate transcription of target genes, thereby enhancing the uptake of low-density lipoprotein (LDL) and promoting lipid biosynthesis. The regulation of SREBP-1 is vital for maintaining cellular lipid homeostasis, as excessive cholesterol accumulation can lead to various metabolic disorders.

Product Image Gallery
Western blot analysis of extracts on Jurkat cells treated with TNF, using Phospho-SREBP-1 (Ser439) Rabbit Polyclonal Antibody (EAB14745) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol