Q9NW08

POLR3B also known as RNA polymerase III subunit B is a crucial component of RNA polymerase III complex, which is responsible for synthesizing small RNAs, such as transfer RNA and ribosomal RNA, essential for protein synthesis and cellular function. This 1,133 amino acid protein is located in nucleus, where POLR3B plays a vital role in transcription process, converting DNA into RNA using ribonucleoside triphosphates as substrates. Proper functioning of POLR3B is critical, as defects in RNA polymerase III activity can lead to various diseases, including neurodegenerative disorders and certain cancers. POLR3B gene is situated on human chromosome 12, a region associated with several genetic disorders, highlighting POLR3B′s importance in both normal cellular processes and disease states.