P45973

HP1α also known as HP1A, CBX5 is a highly conserved nonhistone protein, HP1α is a member of the heterochromatin protein family. HP1α is enriched in the heterochromatin and associated with centromeres. HP1α has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. HP1α has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified.