P43146

DCC is a crucial transmembrane protein consisting of 1447 amino acids, primarily expressed in the developing brain and neural tube, where DCC plays a significant role in mediating directional migration during nervous system development. DCC′s interaction with Netrin-1, a key chemoattractant for commissural axons in the spinal cord, underscores DCC′s importance in guiding neuronal growth and establishing proper neural connections. Loss of DCC expression has been linked to various cancers, including colorectal, breast, endometrial, brain, pancreatic, and prostate cancers, as well as leukemias and neuroblastomas, highlighting DCC′s potential role as a tumor suppressor.