Q92698

Rad54 also known as Rad54L belongs to the DEAD-like helicase superfamily. Rad54 plays a crucial role in DNA repair processes, particularly in homologous recombination, by facilitating the pairing of homologous DNA strands, which is essential for maintaining genomic stability. Rad54 is part of the DEAD-like helicase superfamily and binds to double-stranded DNA, inducing topological changes that promote effective DNA recombination. Rad54 is abundant in tissues such as the testis and spleen, where rapid cell division occurs, and contributes to critical cellular processes. Mutations in the RAD54 gene have been linked to various cancers, including primary lymphoma and colon cancer, highlighting RAD54′s significance in tumorigenesis and genomic integrity maintenance.