Polyclonal Antibodies - Phospho-SSH3 (Ser37) Rabbit Polyclonal Antibody

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Phospho-SSH3 (Ser37) Rabbit Polyclonal Antibody

Catalog #：EAB10825

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB10825-30UL	In Stock	30ul	￡119.90
EAB10825-100UL	In Stock	100ul	￡251.90
EAB10825-200UL	In Stock	200ul	￡405.90

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email us at info@ebiocell.com

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	CUlabSciences	Phone：+44 (0) 1232 330008
	Cambridge House St Thomas' Place Ely,	E-mail：sales@culabsciences.co.uk
United Kingdom	Cambridge CB27 9RD UK	Web：www.culabsciences.co.uk

Product Information
Applications	WB
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000
MW (kDa)	74
Conjugate	Unconjugate
Specificity	Phospho-SSH3 (Ser37) Rabbit Polyclonal Antibody detects endogenous levels of SSH3 protein only when phosphorylated at Ser37.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Slingshot protein phosphatase 3; Slingshot homolog 3; SSH3L; SSH3
Gene Aliases	SSH3
UniProt ID	Q8TE77
Entrez Gene ID	54961

Product Description

SSH3 also known as Slingshot homolog 3, SSH3L is a 659 amino acid protein that plays a crucial role in regulating actin filament dynamics, which is essential for various cellular processes such as motility, shape, and division. SSH3 is localized in both the nucleus and cytoplasm, allowing SSH3 to interact with key regulatory proteins involved in actin remodeling. SSH3 functions as a protein phosphatase, specifically targeting the ADF/Cofilin family of proteins, which are critical for the rapid depolymerization and disassembly of filamentous actin (F-actin) in response to cellular signals. By dephosphorylating ADF and Cofilin, SSH3 reactivates these proteins, enabling them to effectively regulate actin dynamics and maintain cellular architecture. SSH3 is expressed as five isoforms due to alternative splicing, which may contribute to SSH3′s functional diversity and regulatory mechanisms in different cellular contexts.

Product Image Gallery
Western blot analysis of extracts on HuvEc cells, using Phospho-SSH3 (Ser37) Rabbit Polyclonal Antibody (EAB10825) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol