P20823

HNF1α also known as MODY3, TCF1, HNF1A is a member of the hepatocyte nuclear factor family. HNF1α plays a crucial role in regulating the transcription of genes involved in liver function and development, as well as in other tissues like the kidney and small intestine. HNF1α binds to specific DNA sequences to activate or repress target genes, making HNF1α essential for maintaining metabolic homeostasis and proper organ function. Nuclear localization of HNF1α directly influences the expression of genes critical for glucose metabolism and insulin secretion, thereby impacting overall metabolic health. HNF1α interacts with other transcription factors, such as HNF4α and HNF3β, to form a regulatory network that ensures precise control of gene expression during development and in adult tissues.