Q14161

GIT2 is a member of the GIT protein family. GIT2 plays a crucial role in the regulation of G protein-coupled receptor signaling by acting as a GTPase-activating protein for members of the ADP ribosylation factor family, which are essential for vesicular trafficking. GIT2 helps modulate the internalization and resensitization of receptors, thereby influencing cellular responses to external signals. Notably, GIT2 interacts with various proteins, including GIT1, which can impact the dynamics of receptor signaling pathways. By facilitating the inactivation of G protein-coupled receptors, GIT2 ensures that cells can effectively respond to stimuli without becoming overstimulated, highlighting GIT2′s importance in maintaining cellular homeostasis and signaling fidelity.