P61073

CXCR4 also known as CD184, Fusin is a CXC chemokine receptor specific for stromal cell-derived factor-1. CXCR4 is a seven-transmembrane G protein-coupled receptor that resides primarily on the cell surface. CXCR4 is highly expressed in various tissues and plays a critical role in cellular signaling, particularly in immune and developmental processes. CXCR4 interacts with stromal cell-derived factor-1 (SDF-1) to mediate chemotactic migration of immune cells such as T cells and monocytes. CXCR4′s cell surface location enables efficient detection and response to extracellular signals, guiding cell movement during immune responses, tissue repair, and development. CXCR4′s localization to the plasma membrane facilitates a role as a major co-receptor for T-tropic HIV-1, aiding in viral entry into host cells, while SDF-1 acts as an inhibitor of HIV-1 infection, highlighting significance in antiviral research.