P41279

Tpl2 also known as Cot is an oncogene that encodes a member of the serine/threonine protein kinase family. Tpl2 plays a crucial role in cell signaling pathways, particularly in activating the mitogen-activated protein kinase (MAPK) pathway, which regulates cellular processes like proliferation, differentiation, and survival. Tpl2 protein is primarily located in the cytoplasm, where Tpl2 interacts with other signaling molecules to modulate cellular responses to external stimuli. Notably, Tpl2 has been implicated in T lymphocyte activation, highlighting Tpl2′s importance in immune responses. Additionally, Tpl2 protein undergoes post-translational modifications that influence activity and interactions, further underscoring Tpl2′s role in cellular signaling networks. Overexpression of Tpl2 induces MAP kinase activation, and Tpl2′s function is intricately linked to proteins such as Ras and Raf-1, suggesting Tpl2 may form a multimeric complex that regulates downstream signaling events.