SKU-Pack Size | Availability | Size | Price | |
EAB10553-30UL | In Stock | 30ul | £119.90 | |
EAB10553-100UL | In Stock | 100ul | £251.90 | |
EAB10553-200UL | In Stock | 200ul | £405.90 |
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CUlabSciences | Phone:+44 (0) 1232 330008 | |
Cambridge House St Thomas' Place Ely, | E-mail:sales@culabsciences.co.uk | |
United Kingdom | Cambridge CB27 9RD UK | Web:www.culabsciences.co.uk |
Product Information | |
Applications | WB, IHC-P, IF, ELISA |
Species Reactivity | Human, Monkey |
Host / Isotype | Rabbit IgG |
Clonality | Polyclonal |
Applications Dilutions | WB=1:500-2000 IHC-P=1:50-300 IF=1:50-300 |
MW (kDa) | 47 |
Conjugate | Unconjugate |
Specificity | Phospho-β-Arrestin 1 (Ser412) Rabbit Polyclonal Antibody detects endogenous levels of β-arrestin 1 only when phosphorylated at Ser412. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | ARB1; ARR1; ARRB1; AW208571; BARRES; Beta-arrestin-1; Arrestin beta-1 |
Gene Aliases | ARRB1 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. |
Product Image Gallery | |
Western blot analysis of extracts on COS7 cells treated with Etoposide, using β-Arrestin 1 (Ser412) Rabbit Polyclonal Antibody (EAB10553) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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Specific Protocols | |