Q03167

TGF-β Receptor III also known as TGFβ RIII, TGFBR3，betaglycan plays a crucial role in transforming growth factor beta signaling pathway, which regulates cell growth, differentiation, and immune responses. TGFβ RIII is primarily located on cell surfaces and captures and presents TGFβ to signaling receptors, enhancing signaling cascades that influence cellular processes. TGFβ RIII functions as a secreted and single-pass type I membrane protein consisting of 850 amino acids, featuring a ZP domain that facilitates interaction with TGFβ ligands. TGFβ RIII undergoes significant post-translational modifications, including glycosaminoglycan group attachment, vital for function and stability. TGFβ RIII gene is located on human chromosome 1p22.2, highlighting evolutionary conservation and importance across species.