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Beclin-1 Rabbit Polyclonal Antibody
Catalog #£ºEAB10496
  SKU-Pack Size Availability Size Price
EAB10496-30UL In Stock 30ul €115.70
EAB10496-100UL In Stock 100ul €258.70
EAB10496-200UL In Stock 200ul €440.70
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Product Information
Applications WB
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Polyclonal
Applications Dilutions WB=1:1000-5000¡¡
MW (kDa) 52
Conjugate Unconjugate
Specificity Beclin-1 Rabbit Polyclonal Antibody detects endogenous levels of Beclin-1 protein.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) Beclin-1; ATG6; Beclin1; VPS30; Beclin 1 like protein 1
Gene Aliases BECN1
UniProt ID

Q14457

Entrez Gene ID

8678

Product Description

Beclin 1 (BECN1) is a coiled-coil protein that has been implicated as an inhibitor of tumorigenesis. Beclin 1, which associates with Bcl-2, plays a significant role in autophagy. Autophagy is the degradation of cellular proteins in the lysosomes, and when this pathway is suppressed, cell growth is deregulated. Autophagy is controlled by the same signal transduction pathway that induces the phosphorylation of the Ribosomal Protein S6, and both are mediated via amino acids. Beclin 1 expression in various carcinoma cell lines such as MCF7 is low, whereas it is ubiquitously expressed in normal breast tissue. In transfected MCF7 cells, Beclin 1 complements autophagocytosis and, subsequently, inhibits cellular proliferation. Additionally, Beclin 1 shares structural similarity to the yeast autophagy gene product, Apg6, and was one of the first mammalian proteins discovered to mediate autophagy.

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Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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