Q08345

DDR1(discoidin domain receptor tyrosine kinase 1) is a member of the receptor tyrosine kinase family. DDR1 plays a crucial role in mediating cellular responses to the extracellular matrix, particularly collagen, which is vital for tissue development and repair. Upon activation by collagen, DDR1 initiates signaling pathways that influence cell adhesion, migration, and proliferation, thereby contributing to processes such as wound healing and fibrosis. DDR1′s function is highlighted by involvement in various pathological conditions, including cancer and fibrotic diseases, where dysregulation of receptor tyrosine kinases can lead to aberrant cellular behavior.