Polyclonal Antibodies - Phospho-Estrogen receptor α/ERα (Tyr537) Rabbit Polyclonal Antibody

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Phospho-Estrogen receptor α/ERα (Tyr537) Rabbit Polyclonal Antibody

Catalog #：EAB11547

Datasheet

SKU-Pack Size	Availability	Size	Price
EAB11547-30UL	In Stock	30ul	€141.70
EAB11547-100UL	In Stock	100ul	€297.70
EAB11547-200UL	In Stock	200ul	€479.70

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email us at info@ebiocell.com

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	Dianost	Phone：+49 (0) 40 65472-053
	Bullenkoppel 11， 23896 Poggensee,	E-mail：ola@olasciences.com
Germany	Germany	Web：www.olasciences.com

Product Information
Applications	WB, IHC-P, IF, ELISA
Species Reactivity	Human, Mouse, Rat
Host / Isotype	Rabbit IgG
Clonality	Polyclonal
Applications Dilutions	WB=1:500-2000　 IHC-P=1:50-300 IF=1:50-300
MW (kDa)	66
Conjugate	Unconjugate
Specificity	Phospho-Estrogen receptor α/ERα (Tyr537) Rabbit Polyclonal Antibody detects endogenous levels of Estrogen receptor α/ERα protein only when phosphorylated at Tyr537.
Purification	Affinity purification
Concentration	1mg/ml
Format	Liquid
Formulation	In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping	Gel Pack
Storage	Store at -20°C least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4°C for 1-2 weeks.
Research Use	For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry
Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s)	Estrogen receptor 1; ER; ESR; Era; ESRA; ESTRR; NR3A1; ESR1
Gene Aliases	ESR1
UniProt ID	P03372
Entrez Gene ID	2099

Product Description

ERα(Estrogen Receptor α) also known as ESR1 is a ligand-activated transcription factor belonging to the steroid/thyroid hormone receptor superfamily. ERα plays a critical role in regulating the normal function of reproductive tissues. Post-translational modifications (PTMs) of ERα, such as phosphorylation, ubiquitination, sumoylation, acetylation, and methylation, are crucial for modulating activity, stability, cellular localization, and interactions with co-regulatory proteins. For instance, phosphorylation at specific serine residues can enhance or repress ERα′s transcriptional activity, influencing gene expression involved in cell proliferation and differentiation. Ubiquitination targets ERα for proteasomal degradation, thereby controlling receptor levels within the cell and affecting hormonal responsiveness.

Product Image Gallery
Western blot analysis of extracts on 293 cells, using Phospho-Estrogen receptor α/ERα (Tyr537) Rabbit Polyclonal Antibody (EAB11547) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol