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Phospho-IKK¦Â (Tyr188) Rabbit Polyclonal Antibody
Catalog #£ºEAB10126
  SKU-Pack Size Availability Size Price
EAB10126-30UL In Stock 30ul €141.70
EAB10126-100UL In Stock 100ul €297.70
EAB10126-200UL In Stock 200ul €479.70
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Product Information
Applications WB, IHC-P, IF, ELISA
Species Reactivity Human, Mouse, Rat
Host / Isotype Rabbit IgG
Clonality Polyclonal
Applications Dilutions WB=1:500-2000¡¡
IHC-P=1:50-300¡¡
IF=1:50-300
MW (kDa) 87
Conjugate Unconjugate
Specificity Phospho-IKK¦Â (Tyr188) Rabbit Polyclonal Antibody detects endogenous levels of IKK¦Â protein only when phosphorylated at Tyr188.
Purification Affinity purification
Concentration 1mg/ml
Format Liquid
Formulation In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol.
Shipping Gel Pack
Storage Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks.
Research Use For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Application Key

WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry

Reactivity Key

H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected

Product Bioinformatics
Synonym(s) I kappa B kinase beta; IKK2; IKKB; IKK-2; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta; IKBKB
Gene Aliases IKBKB
UniProt ID

O14920

Entrez Gene ID

3551

Product Description

IKKβ also known as IKBKB is a member of the serine/threonine protein kinase family. IKKβ plays a crucial role in the activation of the transcription factor NFκB, which is essential for regulating immune responses, inflammation, and cell survival. Located primarily in the cytoplasm, IKKβ interacts with IκB proteins, facilitating their phosphorylation and subsequent degradation, which allows NFκB to translocate to the nucleus and initiate the transcription of target genes. The proper functioning of IKKβ is vital, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. Additionally, IKKβ undergoes post-translational modifications, such as phosphorylation, which can influence activity and interactions with other proteins, further underscoring importance in cellular signaling pathways.

Product Image Gallery
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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