SKU-Pack Size | Availability | Size | Price | |
EAB10126-30UL | In Stock | 30ul | €141.70 | |
EAB10126-100UL | In Stock | 100ul | €297.70 | |
EAB10126-200UL | In Stock | 200ul | €479.70 |
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Betaclonal | Phone£º+34 (0)91 471 6763 |
29/1 Lomonosovsky Pr, | E-mail£ºtech@betaclonal.com | |
Spain | Madrid, Spain | Web£ºwww.betaclonal.com |
Product Information | |
Applications | WB, IHC-P, IF, ELISA |
Species Reactivity | Human, Mouse, Rat |
Host / Isotype | Rabbit IgG |
Clonality | Polyclonal |
Applications Dilutions | WB=1:500-2000¡¡ IHC-P=1:50-300¡¡ IF=1:50-300 |
MW (kDa) | 87 |
Conjugate | Unconjugate |
Specificity | Phospho-IKK¦Â (Tyr188) Rabbit Polyclonal Antibody detects endogenous levels of IKK¦Â protein only when phosphorylated at Tyr188. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | I kappa B kinase beta; IKK2; IKKB; IKK-2; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta; IKBKB |
Gene Aliases | IKBKB |
UniProt ID | |
Entrez Gene ID |
Product Description | |
IKKβ also known as IKBKB is a member of the serine/threonine protein kinase family. IKKβ plays a crucial role in the activation of the transcription factor NFκB, which is essential for regulating immune responses, inflammation, and cell survival. Located primarily in the cytoplasm, IKKβ interacts with IκB proteins, facilitating their phosphorylation and subsequent degradation, which allows NFκB to translocate to the nucleus and initiate the transcription of target genes. The proper functioning of IKKβ is vital, as dysregulation can lead to various diseases, including cancer and autoimmune disorders. Additionally, IKKβ undergoes post-translational modifications, such as phosphorylation, which can influence activity and interactions with other proteins, further underscoring importance in cellular signaling pathways. |
Product Image Gallery | |
![]() Western blot analysis of extracts on Hela cells, using Phospho-IKK¦Â (Tyr188) Rabbit Polyclonal Antibody (EAB10126) at 1:1000 dilution. The lane on the left is blocked with the phospho peptide.
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Specific Protocols | |