SKU-Pack Size | Availability | Size | Price | |
EAB10081-30UL | In Stock | 30ul | €115.70 | |
EAB10081-100UL | In Stock | 100ul | €258.70 | |
EAB10081-200UL | In Stock | 200ul | €440.70 |
Please select the country you are in to find your local distributor. |
Betaclonal | Phone£º+34 (0)91 471 6763 | |
29/1 Lomonosovsky Pr, | E-mail£ºtech@betaclonal.com | |
Spain | Madrid, Spain | Web£ºwww.betaclonal.com |
Product Information | |
Applications | WB, IHC-P, IF/ICC |
Species Reactivity | Human, Mouse, Rat |
Host / Isotype | Mouse IgG1 |
Clonality | Monoclonal |
Applications Dilutions | WB=1:1000-5000¡¡ IHC-P=1:100-500¡¡ IF/ICC=1:50-300 |
MW (kDa) | 55 |
Conjugate | Unconjugate |
Specificity | Caspase-8 Mouse Monoclonal Antibody detects endogenous levels of Caspase-8 protein. |
Purification | Affinity purification |
Concentration | 1mg/ml |
Format | Liquid |
Formulation | In PBS, pH 7.4, containing 0.02% sodium azide,0.5% BSA and 50% glycerol. |
Shipping | Gel Pack |
Storage | Store at -20¡ãC least 1 year from the date of shipment. avoid repeated freeze/thaw cycles. Aliquots may be stored at +4¡ãC for 1-2 weeks. |
Research Use | For Research Use Only. Not Intended for Diagnostic or Therapeutic Use. |
Application Key WB-Western Blot IP-Immunoprecipitation IHC-Immunohistochemistry IF-Immunofluorescence ICC-Immunocytochemistry FC-Flow Cytometry |
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Reactivity Key H-Human M-Mouse R-Rat Mk-Monkey B-Bovine Pg-Pig Hm-Hamster Dg-Dog C-Chicken X-Xenopus Z-Zebrafish Hr-Horse All-All Species Expected |
Product Bioinformatics | |
Synonym(s) | ALPS2B; CAP4; CASP-8; CASP8; FLICE; MACH; MCH5 |
Gene Aliases | CASP8 |
UniProt ID | |
Entrez Gene ID |
Product Description | |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. |
Product Image Gallery | |
Western blot analysis of extracts on Hela, Mouse Brain, Rat Brain cells, using Caspase-8 Mouse Monoclonal Antibody (EAB10081) at 1:1000 dilution. Secondary antibody Goat Anti-Mouse IgG (H&L)-HRP (EAB21001) at 1:5000 dilution.
Immunohistochemical analysis of paraffin-embedded Mouse spleen tissue, using Caspase-8 Mouse Monoclonal Antibody (EAB10081) at 1:500 dilution.
Immunofluorescence analysis of Hela cell, using Caspase-8 Mouse Monoclonal Antibody (EAB10081)(green) at 1:200 dilution(4¡ã overnight).
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Specific Protocols | |