Protein Substrates - Raloxifene hydrochloride (CAS: 82640-04-8)

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Raloxifene hydrochloride (CAS: 82640-04-8)

Catalog #：EBC51158

Raloxifene hydrochloride
(CAS: 82640-04-8)

SKU-Pack Size	Availability	Size	Price
EBC51158-1ML	In Stock	1mL(10mM in DMSO)	￥390.00
EBC51158-10MG	In Stock	10mg	￥390.00
EBC51158-50MG	In Stock	50mg	￥490.00
EBC51158-100MG	In Stock	100mg	￥790.00

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Product Information

Synonym(s)

Raloxifene HCl, Keoxifene

Chemical Name

[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride

Application

Raloxifene hydrochloride is a SERM of ERα and ERβ

CAS Number

82640-04-8

Purity

≥98%

Molecular Weight

510.04

Molecular Formula

C₂₈H₂₇NO₄S•HCl

SMILES

C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O.Cl

Target & IC50

ER α: IC50 = 0.72 nM
ER β: IC50 = 43 nM
MCF7: IC50 = 0.2 nM

Solubility

DMSO: 25.5 mg/mL (50 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.9606 ml	9.8032 ml	19.6063 ml
5 mM	0.3921 ml	1.9606 ml	3.9213 ml
10 mM	0.1961 ml	0.9803 ml	1.9606 ml
50 mM	0.0392 ml	0.1961 ml	0.3921 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

Raloxifene hydrochloride is a selective estrogen receptor modulator (SERM), binding to ERα and ERβ. Tissue-dependently blocks or activates estrogen-induced transcription. Exhibits estrogen agonist behavior in bone but acts as an anti-estrogen in breast and uterine tissue. Raloxifene hydrochloride exhibits inhibitory effects of progesterone receptor induction by estrogen in D12 rat hypothalamic cells. Raloxifene hydrochloride is a substrate of Estrogen Receptor.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol

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