Protein Agonists, Antagonists and Activators - Purmorphamine (CAS: 483367-10-8)

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Purmorphamine (CAS: 483367-10-8)

Catalog #：EBC51155

Datasheet

Purmorphamine (CAS: 483367-10-8)

SKU-Pack Size	Availability	Size	Price
EBC51155-1ML	In Stock	1mL(10mM in DMSO)	€141.70
EBC51155-1MG	In Stock	5mg	€89.70
EBC51155-5MG	In Stock	5mg	€128.70
EBC51155-10MG	In Stock	10mg	€206.70
EBC51155-25MG	In Stock	25mg	€414.70

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Product Information

Synonym(s)

UNII-PB12M2F8KY, Shh Signaling Antagonist VI

Chemical Name

9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine

Application

Purmorphamine is the first small-molecule agonist developed for the protein Smoothened

CAS Number

483367-10-8

Purity

≥98.0%

Molecular Weight

520.62

Molecular Formula

C₃₁H₃₂N₆O₂

SMILES

C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76

Target & IC50

Sonic hedgehog protein: EC5050 = 1 μM
Smo: IC50 = 1.5 μM

Solubility

DMSO : 50 mg/mL (96.04 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.9208 ml	9.6039 ml	19.2079 ml
5 mM	0.3842 ml	1.9208 ml	3.8416 ml
10 mM	0.1921 ml	0.9604 ml	1.9208 ml
50 mM	0.0384 ml	0.1921 ml	0.3842 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol