USA£º(540) 808-3925
China£º400-117-0038
Italy
Shopping Cart
Sign in \ Register
Purmorphamine (CAS: 483367-10-8)
Catalog #£ºEBC51155
  SKU-Pack Size Availability Size Price
EBC51155-1ML In Stock 1mL(10mM in DMSO) €141.70
EBC51155-1MG In Stock 5mg €89.70
EBC51155-5MG In Stock 5mg €128.70
EBC51155-10MG In Stock 10mg €206.70
EBC51155-25MG In Stock 25mg €414.70
If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com
Please Select The Country You Are In To Find Your Local Distributor.
SBT BioChem Srl Phone£º+39 05 7156 8147
Via Ponte di Bagnolo, 811 Bologna, E-mail£ºinfo@sbtbiochem.it
Italy Italy Web£ºwww.sbtbiochem.it
Product Information
Synonym(s) UNII-PB12M2F8KY, Shh Signaling Antagonist VI
Chemical Name 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Application Purmorphamine is the first small-molecule agonist developed for the protein Smoothened
CAS Number 483367-10-8
Purity ¡Ý98.0%
Molecular Weight 520.62
Molecular Formula C₃₁H₃₂N₆O₂
SMILES C1CCC(CC1)N2C=NC3=C2N=C(N=C3NC4=CC=C(C=C4)N5CCOCC5)OC6=CC=CC7=CC=CC=C76
Target & IC50 Sonic hedgehog protein: EC5050 = 1 ¦ÌM
Smo: IC50 = 1.5 ¦ÌM
Solubility DMSO : 50 mg/mL (96.04 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.9208 ml 9.6039 ml 19.2079 ml
5 mM 0.3842 ml 1.9208 ml 3.8416 ml
10 mM 0.1921 ml 0.9604 ml 1.9208 ml
50 mM 0.0384 ml 0.1921 ml 0.3842 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

Purmorphamine, a purine derivative, has been shown to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo. 

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
Copyright 2015 EbioCell, Inc. All Rights Reserved. ¡¡±¸°¸ºÅ£º½òICP±¸2022005142ºÅ-1