Protein Inhibitors - PD173074 (CAS: 219580-11-7)

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PD173074 (CAS: 219580-11-7)

Catalog #：EBC51147

PD173074 (CAS: 219580-11-7)

SKU-Pack Size	Availability	Size	Price
EBC51147-1ML	In Stock	1mL(10mM in DMSO)	￡64.90
EBC51147-5MG	In Stock	5mg	￡64.90
EBC51147-10MG	In Stock	10mg	￡86.90
EBC51037-50MG	In Stock	50mg	￡196.90
EBC51016-100MG	In Stock	100mg	￡306.90

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Product Information

Synonym(s)

PD 173074, UNII-A4TLL8634Y, PD-173074

Chemical Name

N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea

Application

PD173074 is a poten and selective fibroblast growth factor receptor (FGR) inhibitor

CAS Number

219580-11-7

Purity

≥99.0%

Molecular Weight

523.67

Molecular Formula

C₂₈H₄₁N₇O₃

SMILES

CCN(CC)CCCCNC1=NC2=NC(=C(C=C2C=N1)C3=CC(=CC(=C3)OC)OC)NC(=O)NC(C)(C)C

Target & IC50

FGFR1: IC50 = 21.5 nM
PDGFR: IC50 = 17.6 μM
c-Src: IC50 = 19.8 μM

Solubility

DMSO: 100 mg/mL (190.96 mM)
Ethanol: 100 mg/mL (190.96 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.9096 ml	9.5480 ml	19.0960 ml
5 mM	0.3819 ml	1.9096 ml	3.8192 ml
10 mM	0.1910 ml	0.9548 ml	1.9096 ml
50 mM	0.0382 ml	0.1910 ml	0.3819 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

PD173074 is a cell-permeable pyridopyrimidine compound that has been shown to act as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors {IC50 = 21.5 nM for Flg (FGFR1)}. It has been used to inhibit PDGFR and c-Src only at much higher concentration (IC50 = 17.6 μM, 19.8 μM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 μM. It has also been shown to inhibit the autophosphorylation of endogenous Flg (FGFR1, IC50 <5 nM) and overexpressed Flk-1 (VEGFR2, IC50 <200 nM) in NIH3T3 cells in vitro. Inhibition of FGFR signaling impairs angiogenesis as well as self-renewal of stem cells via ERK1/2 activation. Also indicated as an inhibitor of FGFR-3.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol