Protein Inhibitors - NU 7441 (CAS: 503468-95-9)

Location：Home > Biochemicals > Protein Inhibitors

NU 7441 (CAS: 503468-95-9)

Catalog #：EBC51145

SKU-Pack Size	Availability	Size	Price
EBC51145-1ML	In Stock	1mL(10mM in DMSO)	€115.70
EBC51145-5MG	In Stock	5mg	€63.70
EBC51145-10MG	In Stock	10mg	€115.70
EBC51145-25MG	In Stock	25mg	€193.70
EBC51145-50MG	In Stock	50mg	€323.70

If you want to get a larger packsize, Please contact your local distributor or
email us atinfo@ebiocell.com

Please Select The Country You Are In To Find Your Local Distributor.

	Dianost	Phone：+49 (0) 40 65472-053
	Bullenkoppel 11， 23896 Poggensee,	E-mail：ola@olasciences.com
Germany	Germany	Web：www.olasciences.com

Product Information

Synonym(s)

KU-57788, KU 57788

Chemical Name

8-dibenzothiophen-4-yl-2-morpholin-4-ylchromen-4-one

Application

NU7441 is a potent novel DNA-PK inhibitor

CAS Number

503468-95-9

Purity

≥98.0%

Molecular Weight

413.49

Molecular Formula

C₂₅H₁₉NO₃S

SMILES

C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56

Target & IC50

DNA-PK: IC50 = 14 nM
PI3K : IC50 = 5 μM

Solubility

DMSO: 15 mg/mL (36.28 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4184 ml	12.0922 ml	24.1844 ml
5 mM	0.4837 ml	2.4184 ml	4.8369 ml
10 mM	0.2418 ml	1.2092 ml	2.4184 ml
50 mM	0.0484 ml	0.2418 ml	0.4837 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

NU 7441 is a selective and potent DNA-PK inhibitor (IC50 14nM) and P13K inhibitor (IC50 5uM). It is reported enhance the cytotoxic effects of radiation in cancer cell lines and potentiate the effects of etoposide and doxorubicin. NU 7441 is also reported to enhance the efficiency of CRISPR-Cas9 mediated homology-directed repair (HDR) 2 to 4 fold and decrease nonhomologous end-joining (NHEJ) frequency by 2 fold.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol