Protein Inhibitors - Nocodazole (CAS: 31430-18-9)

Nocodazole (CAS: 31430-18-9)

Catalog #：EBC51144

Nocodazole (CAS: 31430-18-9)

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Product Information

Synonym(s)

Nocodazolum, ChEMBL9514, Oncodazole,

Chemical Name

methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

Application

Nocodazole is a potent Tubulin production inhibitor, anti-neoplastic agent, and inhibitor of mitosis

CAS Number

31430-18-9

Purity

≥98.0%

Molecular Weight

301.32

Molecular Formula

C₁₄H₁₁N₃O₃S

SMILES

COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C3=CC=CS3

Target & IC50

Abl: IC50 = 0.21μM

Solubility

DMSO: 20 mg/mL (66.37 mM)

Preparing Stock Solutions

Shipping

Room Temperature

Storage

Room Temperature

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Nocodazole is a rapidly-reversible inhibitor of microtubule polymerization, also inhibits Abl, Abl (E255K) and Abl (T315I) with IC50 of 0.21 μM, 0.53 μM and 0.64 μM, respectively. Nocodazole will bind to β-Tb and block polymerization, arrest mammalian cells in mitosis and release them into cytokinesis and G1 as well as mis-regulate mitotic kinases.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol