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Location：Home > Biochemicals > Protein Inhibitors
LY 2157299 (CAS: 700874-72-2)
Catalog #：EBC51136
LY 2157299 (CAS: 700874-72-2)
  SKU-Pack Size Availability Size Price
EBC51016-1ML In Stock 1mL(10mM in DMSO) ￥790.00
EBC51037-5MG In Stock 5mg ￥690.00
EBC51038-10MG In Stock 10mg ￥990.00
EBC51038-25MG In Stock 25mg ￥1990.00
EBC51037-50MG In Stock 50mg ￥2990.00
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Product Information
Synonym(s) LY 2157299, LY-2157299, Galunisertib
Chemical Name 4-(2-(6-Methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxamide
Application LY2157299 is a potent TGF β RI inhibitor
CAS Number 700874-72-2
Purity ≥98.0%
Molecular Weight 369.42
Molecular Formula C₂₂H₁₉N₅O
SMILES CC1=CC=CC(=N1)C2=NN3CCCC3=C2C4=C5C=C(C=CC5=NC=C4)C(=O)N
Target & IC50 Flk-1: IC50 = 442 nM
TGFβ RI: IC50 = 56 nM
Solubility DMSO: 74 mg/mL (200.31 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.7069 ml 13.5347 ml 27.0695 ml
5 mM 0.5414 ml 2.7069 ml 5.4139 ml
10 mM 0.2707 ml 1.3535 ml 2.7070 ml
50 mM 0.0541 ml 0.2707 ml 0.5414 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

LY 2157299 is a potent inhibitor of Transforming Growth factor-Beta Receptor I (TGF-BetaR). TGF-Beta1 is involved in the control of cell growth, proliferation, differentiation, and apoptosis. LY2157299 is reported to disrupt Smad-2 phosphorylation in Human Umbilical Vein Endothelial Cells (HUVEC) and inhibit the growth and migration of tumor cells.
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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