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LDN 193189 Hydrochloride (CAS: 1062368-62-0)
Catalog #：EBC51134
Datasheet
LDN 193189 Hydrochloride
(CAS: 1062368-62-0)
  SKU-Pack Size Availability Size Price
EBC51016-1ML In Stock 1mL(10mM in DMSO) ￥1490.00
EBC51037-1MG In Stock 1mg ￥490.00
EBC51038-5MG In Stock 5mg ￥890.00
EBC51038-10MG In Stock 10mg ￥1390.00
EBC51037-25MG In Stock 25mg ￥2490.00
If you want to get a larger packsize, Please contact your local distributor or
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Product Information
Synonym(s) LDN-193189 hydrochloride, LDN193189 HCl
Chemical Name 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
Application LDN 193189 HCl is a selective BMP signaling inhibitor
CAS Number 1062368-62-0
Purity ≥98.0%
Molecular Weight 442.94
Molecular Formula C₂₅H₂₂N₆ HCl
SMILES C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl
Target & IC50 ALK2: IC50 = 5 nM
ALK3: IC50 = 30 nM
Solubility DMSO: 55.23mg/ml （100 mM）
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.2576 ml 11.2881 ml 22.5763 ml
5 mM 0.4515 ml 2.2576 ml 4.5153 ml
10 mM 0.2258 ml 1.1288 ml 2.2576 ml
50 mM 0.0452 ml 0.2258 ml 0.4515 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification. The salt-based form of LDN193189 has higher solubility in DMSO than LDN193189 
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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