Other Biochemicals - LDN 193189 Hydrochloride (CAS: 1062368-62-0)

LDN 193189 Hydrochloride (CAS: 1062368-62-0)

Catalog #：EBC51134

LDN 193189 Hydrochloride
(CAS: 1062368-62-0)

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Product Information

Synonym(s)

LDN-193189 hydrochloride, LDN193189 HCl

Chemical Name

4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Application

LDN 193189 HCl is a selective BMP signaling inhibitor

CAS Number

1062368-62-0

Purity

≥98.0%

Molecular Weight

442.94

Molecular Formula

C₂₅H₂₂N₆ HCl

SMILES

C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3.Cl

Target & IC50

ALK2: IC50 = 5 nM
ALK3: IC50 = 30 nM

Solubility

DMSO: 55.23mg/ml （100 mM）

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification. The salt-based form of LDN193189 has higher solubility in DMSO than LDN193189

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol