Other Biochemicals - IQ-1 (CAS: 331001-62-8)

IQ-1 (CAS: 331001-62-8)

Catalog #：EBC51119

IQ-1 (CAS: 331001-62-8)

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Product Information

Synonym(s)

IQ1, Wnt pathway activator

Chemical Name

2-[2-(4-Acetylphenyl)diazenyl]-2-(3,4-dihydro-3,3-dimethyl-1(2H)-isoquinolinylidene)acetamide

Application

IQ-1 is a cell-permeable tetrahydroisoquinolinylidene

CAS Number

331001-62-8

Purity

≥98.0%

Molecular Weight

362.42

Molecular Formula

C21H22N4O2

SMILES

CC(=O)C1=CC=C(C=C1)N=NC(C2C3=CC=CC=C3CC(N2)(C)C)C(=O)N

Target & IC50

β-catenin/p300

Solubility

DMSO: 72 mg/mL (198.66 mM)
Ethanol: 7 mg/mL (19.31 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
IQ-1 is a selective inhibitor of Beta-catenin/p300 signaling by binding to protein phosphatase 2. It is used to maintain embryonic cell pluripotency in Wnt3a-treated cells and prevent spontaneous differentiation. It is also reported to upregulate the expression of Sox2 and Oct4 transcription factors.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol