Product Information |
Synonym(s) |
BCRP inhibitor, Ko-143 |
Chemical Name |
(3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester |
Application |
Ko 143 is a selective BCRP multidrug transporter inhibitor |
CAS Number |
461054-93-3 |
Purity |
≥99.0% |
Molecular Weight |
469.57 |
Molecular Formula |
C₂₆H₃₅N₃O₅ |
SMILES |
CC(C)C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H](NC3=O)CCC(=O)OC(C)(C)C)C4=C(N2)C=C(C=C4)OC |
Target & IC50 |
ABCG2: IC50 = 5 nM (human) MRP1: IC50 = 2 μM (human) MRP2: IC50 >50 μM (human) |
Solubility |
DMSO: 48 mg/mL (100.22 mM) |
Preparing Stock Solutions |
ConcentrationSolventMass |
1 mg |
5 mg |
10 mg |
1 mM |
2.1296 ml |
10.6480 ml |
21.2961 ml |
5 mM |
0.4259 ml |
2.1296 ml |
4.2592 ml |
10 mM |
0.2130 ml |
1.0648 ml |
2.1296 ml |
50 mM |
0.0426 ml |
0.2130 ml |
0.4259 ml |
|
Shipping |
Gel Pack |
Storage |
Store at -20°C |
Research Use |
For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use. |