Protein Inhibitors - HPI-1 (CAS: 599150-20-6)

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HPI-1 (CAS: 599150-20-6)

Catalog #：EBC51108

HPI-1 (CAS: 599150-20-6)

SKU-Pack Size	Availability	Size	Price
EBC51108-5MG	In Stock	5mg	￡163.90
EBC51108-10MG	In Stock	10mg	￡262.90
EBC51108-50MG	In Stock	50mg	￡1076.90

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Product Information

Synonym(s)

ST093553, AC1MFWGY, Hedgehog pathway inhibitor

Chemical Name

2-Methoxyethyl-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate

Application

HPI-1 is A Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor

CAS Number

599150-20-6

Purity

≥98.0%

Molecular Weight

463.52

Molecular Formula

C₂₇H₂₉NO₆

SMILES

CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O

Target & IC50

Shh: IC50 = 1.5 μM
Gli1: IC50 = 6 μM

Solubility

Soluble in DMSO to 100 mM and in ethanol to 100 mM

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.1574 ml	10.7870 ml	21.5740 ml
5 mM	0.4315 ml	2.1574 ml	4.3148 ml
10 mM	0.2157 ml	1.0787 ml	2.1574 ml
50 mM	0.0431 ml	0.2157 ml	0.4315 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

HPI-1 is a hedgehog (Hh) signaling inhibitor without significantly effecting Wnt signaling. It inhibits Gli1 and Gli2 induced activation and the proliferation of SmoM2 expressing cell lines. Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol