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HPI-1 (CAS: 599150-20-6)
Catalog #£ºEBC51108
  SKU-Pack Size Availability Size Price
EBC51108-5MG In Stock 5mg €193.70
EBC51108-10MG In Stock 10mg €310.70
EBC51108-50MG In Stock 50mg €1272.70
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Product Information
Synonym(s) ST093553, AC1MFWGY, Hedgehog pathway inhibitor
Chemical Name 2-Methoxyethyl-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-4,6,7,8-tetrahydro-1H-quinoline-3-carboxylate
Application HPI-1 is A Hedgehog pathway inhibitor; Gli1/Gli2 inhibitor
CAS Number 599150-20-6
Purity ¡Ý98.0%
Molecular Weight 463.52
Molecular Formula C₂₇H₂₉NO₆
SMILES CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O
Target & IC50 Shh: IC50 = 1.5 ¦ÌM
Gli1: IC50 = 6 ¦ÌM
Solubility Soluble in DMSO to 100 mM and in ethanol to 100 mM
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.1574 ml 10.7870 ml 21.5740 ml
5 mM 0.4315 ml 2.1574 ml 4.3148 ml
10 mM 0.2157 ml 1.0787 ml 2.1574 ml
50 mM 0.0431 ml 0.2157 ml 0.4315 ml
Shipping Gel Pack
Storage Store at -20¡ãC
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

HPI-1 is a hedgehog (Hh) signaling inhibitor without significantly effecting Wnt signaling. It inhibits Gli1 and Gli2 induced activation and the proliferation of SmoM2 expressing cell lines. Hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation). Also inhibits Hh pathway activation.

Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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