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Location：Home > Biochemicals > Protein Agonists, Antagonists and Activators
GW 4064 (CAS: 278779-30-9)
Catalog #：EBC51104
Datasheet
GW 4064 (CAS: 278779-30-9)
  SKU-Pack Size Availability Size Price
EBC51104-1ML In Stock 1mL(10mM in DMSO) ￥690.00
EBC51104-5MG In Stock 5mg ￥590.00
EBC51104-10MG In Stock 10mg ￥890.00
EBC51104-50MG In Stock 50mg ￥2590.00
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Product Information
Synonym(s) GW-4064, GW4064
Chemical Name 3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid
Application GW 4064 is a novel nonsteroidal FXR nuclear receptor activator
CAS Number 278779-30-9
Purity ≥99%
Molecular Weight 542.84
Molecular Formula C₂₈H₂₂Cl₃NO₄
SMILES ClC(C=CC=C1Cl)=C1C2=NOC(C(C)C)=C2COC(C=C3)=CC(Cl)=C3/C=C/C4=CC(C(O)=O)=CC=C4
Target & IC50 FXR: IC50 = 64 nM
FXR: EC5050 = 15 nM
Solubility DMSO: 100 mg/mL (184.22 mM)
Preparing Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.8422 ml 9.2108 ml 18.4216 ml
5 mM 0.3684 ml 1.8422 ml 3.6843 ml
10 mM 0.1842 ml 0.9211 ml 1.8422 ml
50 mM 0.0368 ml 0.1842 ml 0.3684 ml
Shipping Gel Pack
Storage Store at -20°C
Research Use For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.
Product Description

GW 4064 is a selective and potent agonist of the Farnesoid X receptor, a regulator of bile acid and lipid homeostasis. It does not react with the retinoic acid receptor at concentrations of up to 1uM. 
Specific Protocols
>> Western Blotting Protocol >> Immunoprecipitation Protocol
>> Immunohistochemistry Protocol >> Immunofluorescence Protocol
>> Immunocytochemistry Protocol >> Flow Cytometry Protocol
>> ChIP Protocol >> ELISA Protocol
>> HPLC Protocol >> PCR Protocol
For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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