Protein Agonists, Antagonists and Activators

GW 4064 (CAS: 278779-30-9)

Catalog #：EBC51104

GW 4064 (CAS: 278779-30-9)

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Product Information

Synonym(s)

GW-4064, GW4064

Chemical Name

3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoic acid

Application

GW 4064 is a novel nonsteroidal FXR nuclear receptor activator

CAS Number

278779-30-9

Purity

≥99%

Molecular Weight

542.84

Molecular Formula

C₂₈H₂₂Cl₃NO₄

SMILES

ClC(C=CC=C1Cl)=C1C2=NOC(C(C)C)=C2COC(C=C3)=CC(Cl)=C3/C=C/C4=CC(C(O)=O)=CC=C4

Target & IC50

FXR: IC50 = 64 nM
FXR: EC5050 = 15 nM

Solubility

DMSO: 100 mg/mL (184.22 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
GW 4064 is a selective and potent agonist of the Farnesoid X receptor, a regulator of bile acid and lipid homeostasis. It does not react with the retinoic acid receptor at concentrations of up to 1uM.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol