Other Biochemicals - GSK 923295 (CAS: 1088965-37-0)

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GSK 923295 (CAS: 1088965-37-0)

Catalog #：EBC51103

Datasheet

GSK 923295 (CAS: 1088965-37-0)

SKU-Pack Size	Availability	Size	Price
EBC51103-1ML	In Stock	1mL(10mM in DMSO)	￡218.90
EBC51103-1MG	In Stock	1mg	￡42.90
EBC51103-5MG	In Stock	5mg	￡108.90
EBC51103-10MG	In Stock	10mg	￡196.90
EBC51103-25MG	In Stock	25mg	￡405.90

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Product Information

Synonym(s)

GSK-923295

Chemical Name

3-chloro-N-[(2S)-1-[[2-(dimethylamino)acetyl]amino]-3-[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]propan-2-yl]-4-propan-2-yloxybenzamide

Application

GSK 923295 is a specific allosteric inhibitor of CENP-E kinesin motor ATPase

CAS Number

1088965-37-0

Purity

≥99.0%

Molecular Weight

592.13

Molecular Formula

C₃₂H₃₈ClN₅O₄

SMILES

C[C@@H](C1=CC=CN2C1=NC(=C2)C3=CC=C(C=C3)C[C@@H](CNC(=O)CN(C)C)NC(=O)C4=CC(=C(C=C4)OC(C)C)Cl)O

Target & IC50

CENP-E

Solubility

DMSO: 100 mg/mL (168.88 mM)
Ethanol: 100 mg/mL (168.88 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.6888 ml	8.4441 ml	16.8882 ml
5 mM	0.3378 ml	1.6888 ml	3.3776 ml
10 mM	0.1689 ml	0.8444 ml	1.6888 ml
50 mM	0.0338 ml	0.1689 ml	0.3378 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description

GSK 923295 is a potent and selective mitotic kinesin Centromere protein E (CENP-E) inhibitor, a protein that accumulates in the G2 phase of the cell cycle. It is proposed to be one of the motors responsible for mammalian chromosome movement and spindle elongation. GSK923295 induces mitotic arrest and chromosome alignment failure. It is reported to be a potent inhibitor of tumor cell growth, which is further enhanced when MEK/ERK signaling is also inhibited.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol