Protein Inhibitors - Doxycycline Hyclate (CAS: 24390-14-5)

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Doxycycline Hyclate (CAS: 24390-14-5)

Catalog #：EBC51092

Doxycycline Hyclate
(CAS: 24390-14-5)

SKU-Pack Size	Availability	Size	Price
EBC51092-1ML	In Stock	1mL(10mM in DMSO)	$88.50
EBC51092-1G	In Stock	1g	$58.50
EBC51092-5G	In Stock	5g	$148.50

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Product Information

Synonym(s)

Doxycycline hydrochloride hemiethanolate hemihydrate, WC2031

Chemical Name

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hyclate

Application

Doxycycline Hyclate is an antimicrobial tetracycline that acts as an inhibitor of MMP-1, MMP-8 and MMP-9

CAS Number

24390-14-5

Purity

≥99.0%

Molecular Weight

512.94

Molecular Formula

C₂₂H₂₄N₂O₈•HCl

SMILES

CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O

Target & IC50

collagen synthesis: IC50 = 25 μM
MMP-8: IC50 = 30 μM
MMP-1: IC50 = 300 μM

Solubility

DMSO : 240 mg/mL (467.89 mM)
H₂O : 13.89 mg/mL (27.08 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.9495 ml	9.7477 ml	19.4955 ml
5 mM	0.3899 ml	1.9495 ml	3.8991 ml
10 mM	0.1950 ml	0.9748 ml	1.9496 ml
50 mM	0.0390 ml	0.1950 ml	0.3899 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Doxycycline is a synthetic oxytetracycline broad-spectrum antibiotic, used to treat a variety of infections such as Lyme disease, Rickettsia, Brucella melitensis, Chlamydia pneumoniae, and others. It is also an inhibitor of matrix metalloproteases and useful in regulating inducible gene expression in Tet-ON/Off systems.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol