Protein Inhibitors - MK-2206 dihydrochloride (CAS: 1032350-13-2)

MK-2206 dihydrochloride (CAS: 1032350-13-2)

Catalog #：EBC51088

MK-2206 dihydrochloride (CAS: 1032350-13-2)

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Product Information

Synonym(s)

MK-2206 2HCl, MK2206

Chemical Name

8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one;dihydrochloride

Application

MK-2206 dihydrochloride is a highly selective pan-Akt inhibitor activated by the pleckstrin homology domain

CAS Number

1032350-13-2

Purity

≥99.5%

Molecular Weight

480.39

Molecular Formula

C₂₅H₂₁N₅O•2HCl

SMILES

C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl

Target & IC50

Akt1: IC50 = 8 nM
Akt2: IC50 = 12 nM
Akt3: IC50 = 65 nM

Solubility

DMSO: 12.5 mg/mL (26.02 mM)
H₂O: 1 mg/mL (2.08 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
MK-2206 is a highly allosteric selective Akt1,2,3 (IC50 5nM, 12nM, 65nM) inhibitor. It is reported to inhibit the proliferation of cancer cell lines when used synergistically with cytotoxic agents such as erlotinib or lapatinib and significantly enhances cell apoptosis.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol