Protein Inhibitors - DAPT (CAS: 208255-80-5)

DAPT (CAS: 208255-80-5)

Catalog #：EBC51084

DAPT (CAS: 208255-80-5)

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Product Information

Synonym(s)

γ-Secretase inhibitor

Chemical Name

N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-(S)-phenylglycine t-butyl ester

Application

DAPT is a potent and specific inhibitor of γ-secretase

CAS Number

208255-80-5

Purity

≥99.0%

Molecular Weight

432.46

Molecular Formula

C₂₃H₂₆F₂N₂O₄

SMILES

C[C@@H](C(=O)N[C@@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

Target & IC50

Aβ: IC50 = 115 nM
Aβ42: IC50 = 200 nM

Solubility

DMSO: 86 mg/mL (198.86 mM)
Ethanol: 41 mg/mL (94.81 mM)

Preparing Stock Solutions

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
DAPT is a potent inhibitor of the gamma-secretase complex, which is an internal protease that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. DAPT also indirectly inhibits the Notch protein. It is reported promote neuronal differentiation and enhance the apoptosis of human tongue carcinoma cells.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol