Other Biochemicals - Cyclopamine (CAS: 4449-51-8)

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Cyclopamine (CAS: 4449-51-8)

Catalog #：EBC51082

Datasheet

Cyclopamine (CAS: 4449-51-8)

SKU-Pack Size	Availability	Size	Price
EBC51082-1ML	In Stock	1mL(10mM in DMSO)	€76.70
EBC51082-5MG	In Stock	5mg	€76.70
EBC51082-10MG	In Stock	10mg	€102.70
EBC51082-25MG	In Stock	25mg	€141.70
EBC51082-50MG	In Stock	50mg	€310.70

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Product Information

Synonym(s)

11-Deoxojervine, Hh signaling inhibitor

Chemical Name

(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a, 4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro- 3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'( 3'H)-furo[3,2-b]pyridin]-3-ol

Application

Cyclopamine is a hedgehog signaling pathway and Smo inhibitor

CAS Number

4449-51-8

Purity

≥98.0%

Molecular Weight

411.63

Molecular Formula

C₂₇H₄₁NO₂

SMILES

CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1

Target & IC50

Smoothened: IC50 = 46 nM

Solubility

Ethanol : 41 mg/mL (99.61 mM)

Preparing Stock Solutions

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4294 ml	12.1471 ml	24.2943 ml
5 mM	0.4859 ml	2.4294 ml	4.8589 ml
10 mM	0.2429 ml	1.2147 ml	2.4294 ml
50 mM	0.0486 ml	0.2429 ml	0.4859 ml

Shipping

Gel Pack

Storage

Store at -20°C

Research Use

For Research Use Only. Not Intended for Diagnostic Or Therapeutic Use.

Product Description
Cyclopamine is a steroidal alkaloid inhibitor of the hedgehog signaling pathway (Hh), an essential pathway for embryonic development. It is reported to be capable of inducing differentiation of stem cells into endocrine cells and various anti-cancer applications by suppressing excess Hh activity.

Specific Protocols

>>	Western Blotting Protocol	>>	Immunoprecipitation Protocol
>>	Immunohistochemistry Protocol	>>	Immunofluorescence Protocol
>>	Immunocytochemistry Protocol	>>	Flow Cytometry Protocol
>>	ChIP Protocol	>>	ELISA Protocol
>>	HPLC Protocol	>>	PCR Protocol